Development of a Visually Calculated SUVmean (HIT Score) on Screening PSMA PET/CT to Predict Treatment Response to 177Lu-PSMA Therapy: Comparison with Quantitative SUVmean and Patient Outcomes

Mina Swiha; Nathan Papa; Zahra Sabahi; Narjess Ayati; Nikeith John; Sarennya Pathmanandavel; Megan Crumbaker; Sherrington Li; Shikha Agrawal; Maria Ayers; Adam Hickey; Shikha Sharma; Andrew Nguyen; Louise Emmett

doi:10.2967/jnumed.123.267014

Research ArticleClinical Investigation

Development of a Visually Calculated SUV_mean (HIT Score) on Screening PSMA PET/CT to Predict Treatment Response to ¹⁷⁷Lu-PSMA Therapy: Comparison with Quantitative SUV_mean and Patient Outcomes

Mina Swiha, Nathan Papa, Zahra Sabahi, Narjess Ayati, Nikeith John, Sarennya Pathmanandavel, Megan Crumbaker, Sherrington Li, Shikha Agrawal, Maria Ayers, Adam Hickey, Shikha Sharma, Andrew Nguyen and Louise Emmett

Journal of Nuclear Medicine June 2024, 65 (6) 904-908; DOI: https://doi.org/10.2967/jnumed.123.267014

Mina Swiha

1Department of Theranostics and Nuclear Medicine, St. Vincent’s Hospital, Sydney, New South Wales, Australia;

2Nuclear Medicine Division, Department of Medical Imaging, University of Western Ontario, London, Ontario, Canada;

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Nathan Papa

3Garvan Institute of Medical Research, Sydney, New South Wales, Australia;

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Zahra Sabahi

1Department of Theranostics and Nuclear Medicine, St. Vincent’s Hospital, Sydney, New South Wales, Australia;

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Narjess Ayati

1Department of Theranostics and Nuclear Medicine, St. Vincent’s Hospital, Sydney, New South Wales, Australia;

3Garvan Institute of Medical Research, Sydney, New South Wales, Australia;

4St. Vincent’s Clinical School, University of New South Wales, Sydney, New South Wales, Australia; and

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Nikeith John

1Department of Theranostics and Nuclear Medicine, St. Vincent’s Hospital, Sydney, New South Wales, Australia;

4St. Vincent’s Clinical School, University of New South Wales, Sydney, New South Wales, Australia; and

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Sarennya Pathmanandavel

1Department of Theranostics and Nuclear Medicine, St. Vincent’s Hospital, Sydney, New South Wales, Australia;

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Megan Crumbaker

1Department of Theranostics and Nuclear Medicine, St. Vincent’s Hospital, Sydney, New South Wales, Australia;

3Garvan Institute of Medical Research, Sydney, New South Wales, Australia;

4St. Vincent’s Clinical School, University of New South Wales, Sydney, New South Wales, Australia; and

5Kinghorn Cancer Centre, St. Vincent’s Hospital, Sydney, New South Wales, Australia

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Sherrington Li

1Department of Theranostics and Nuclear Medicine, St. Vincent’s Hospital, Sydney, New South Wales, Australia;

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Shikha Agrawal

1Department of Theranostics and Nuclear Medicine, St. Vincent’s Hospital, Sydney, New South Wales, Australia;

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Maria Ayers

1Department of Theranostics and Nuclear Medicine, St. Vincent’s Hospital, Sydney, New South Wales, Australia;

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Adam Hickey

1Department of Theranostics and Nuclear Medicine, St. Vincent’s Hospital, Sydney, New South Wales, Australia;

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Shikha Sharma

1Department of Theranostics and Nuclear Medicine, St. Vincent’s Hospital, Sydney, New South Wales, Australia;

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Andrew Nguyen

1Department of Theranostics and Nuclear Medicine, St. Vincent’s Hospital, Sydney, New South Wales, Australia;

4St. Vincent’s Clinical School, University of New South Wales, Sydney, New South Wales, Australia; and

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Louise Emmett

1Department of Theranostics and Nuclear Medicine, St. Vincent’s Hospital, Sydney, New South Wales, Australia;

3Garvan Institute of Medical Research, Sydney, New South Wales, Australia;

4St. Vincent’s Clinical School, University of New South Wales, Sydney, New South Wales, Australia; and

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Journal of Nuclear Medicine

Vol. 65, Issue 6

June 1, 2024

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Development of a Visually Calculated SUV_mean (HIT Score) on Screening PSMA PET/CT to Predict Treatment Response to ¹⁷⁷Lu-PSMA Therapy: Comparison with Quantitative SUV_mean and Patient Outcomes

Journal of Nuclear Medicine Jun 2024, 65 (6) 904-908; DOI: 10.2967/jnumed.123.267014

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Development of a Visually Calculated SUV_mean (HIT Score) on Screening PSMA PET/CT to Predict Treatment Response to ¹⁷⁷Lu-PSMA Therapy: Comparison with Quantitative SUV_mean and Patient Outcomes

Journal of Nuclear Medicine Jun 2024, 65 (6) 904-908; DOI: 10.2967/jnumed.123.267014

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Keywords

SUVmean
prostate cancer
177Lu-PSMA
PSMA PET/CT

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Development of a Visually Calculated SUV_mean (HIT Score) on Screening PSMA PET/CT to Predict Treatment Response to ¹⁷⁷Lu-PSMA Therapy: Comparison with Quantitative SUV_mean and Patient Outcomes

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