[11C]PS13 Demonstrates Pharmacologically Selective and Substantial Binding to Cyclooxygenase-1 in the Human Brain

Nafiseh Ghazanfari; Jeih-San Liow; Min-Jeong Kim; Raven Cureton; Adrian Lee; Carson Knoer; Madeline Jenkins; Jinsoo Hong; Jose A. Montero Santamaria; H. Umesha Shetty; Anthony Galassi; Paul Wighton; Martin Nørgaard; Douglas N. Greve; Sami S. Zoghbi; Victor W. Pike; Robert B. Innis; Paolo Zanotti-Fregonara

doi:10.2967/jnumed.124.267928

Research ArticleClinical Investigation

[¹¹C]PS13 Demonstrates Pharmacologically Selective and Substantial Binding to Cyclooxygenase-1 in the Human Brain

Nafiseh Ghazanfari, Jeih-San Liow, Min-Jeong Kim, Raven Cureton, Adrian Lee, Carson Knoer, Madeline Jenkins, Jinsoo Hong, Jose A. Montero Santamaria, H. Umesha Shetty, Anthony Galassi, Paul Wighton, Martin Nørgaard, Douglas N. Greve, Sami S. Zoghbi, Victor W. Pike, Robert B. Innis and Paolo Zanotti-Fregonara

Journal of Nuclear Medicine January 2025, 66 (1) 117-122; DOI: https://doi.org/10.2967/jnumed.124.267928

Nafiseh Ghazanfari

1Molecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland;

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Jeih-San Liow

1Molecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland;

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Min-Jeong Kim

1Molecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland;

2Stony Brook University School of Medicine, Stony Brook, New York;

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Raven Cureton

1Molecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland;

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Adrian Lee

1Molecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland;

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Carson Knoer

1Molecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland;

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Madeline Jenkins

1Molecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland;

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Jinsoo Hong

1Molecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland;

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Jose A. Montero Santamaria

1Molecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland;

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H. Umesha Shetty

1Molecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland;

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Anthony Galassi

1Molecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland;

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Paul Wighton

3Athinoula A. Martinos Center for Biomedical Imaging, Boston, Massachusetts; and

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Martin Nørgaard

1Molecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland;

4University of Copenhagen, Copenhagen, Denmark

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Douglas N. Greve

3Athinoula A. Martinos Center for Biomedical Imaging, Boston, Massachusetts; and

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Sami S. Zoghbi

1Molecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland;

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Victor W. Pike

1Molecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland;

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Robert B. Innis

1Molecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland;

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Paolo Zanotti-Fregonara

1Molecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland;

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January 1, 2025

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[¹¹C]PS13 Demonstrates Pharmacologically Selective and Substantial Binding to Cyclooxygenase-1 in the Human Brain

Journal of Nuclear Medicine Jan 2025, 66 (1) 117-122; DOI: 10.2967/jnumed.124.267928

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[¹¹C]PS13 Demonstrates Pharmacologically Selective and Substantial Binding to Cyclooxygenase-1 in the Human Brain

Journal of Nuclear Medicine Jan 2025, 66 (1) 117-122; DOI: 10.2967/jnumed.124.267928

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[11C]PS13
COX-1
brain
human
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[¹¹C]PS13 Demonstrates Pharmacologically Selective and Substantial Binding to Cyclooxygenase-1 in the Human Brain

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