Patterns of Early Neocortical Amyloid-β Accumulation: A PET Population-Based Study

Emily E. Lecy; Hoon-Ki Min; Christopher J. Apgar; Daniela D. Maltais; Emily S. Lundt; Sabrina M. Albertson; Matthew L. Senjem; Christopher G. Schwarz; Hugo Botha; Jonathan Graff-Radford; David T. Jones; Prashanthi Vemuri; Kejal Kantarci; David S. Knopman; Ronald C. Petersen; Clifford R. Jack; Jeyeon Lee; Val J. Lowe

doi:10.2967/jnumed.123.267150

Research ArticleClinical Investigation

Patterns of Early Neocortical Amyloid-β Accumulation: A PET Population-Based Study

Emily E. Lecy, Hoon-Ki Min, Christopher J. Apgar, Daniela D. Maltais, Emily S. Lundt, Sabrina M. Albertson, Matthew L. Senjem, Christopher G. Schwarz, Hugo Botha, Jonathan Graff-Radford, David T. Jones, Prashanthi Vemuri, Kejal Kantarci, David S. Knopman, Ronald C. Petersen, Clifford R. Jack, Jeyeon Lee and Val J. Lowe

Journal of Nuclear Medicine July 2024, 65 (7) 1122-1128; DOI: https://doi.org/10.2967/jnumed.123.267150

Emily E. Lecy

1Department of Radiology, Mayo Clinic, Rochester, Minnesota;

2Department of Neuroscience, University of Minnesota, Minneapolis, Minnesota;

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Hoon-Ki Min

1Department of Radiology, Mayo Clinic, Rochester, Minnesota;

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Christopher J. Apgar

1Department of Radiology, Mayo Clinic, Rochester, Minnesota;

2Department of Neuroscience, University of Minnesota, Minneapolis, Minnesota;

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Daniela D. Maltais

1Department of Radiology, Mayo Clinic, Rochester, Minnesota;

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Emily S. Lundt

3Division of Biostatistics, Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota;

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Sabrina M. Albertson

3Division of Biostatistics, Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota;

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Matthew L. Senjem

4Department of Technology, Mayo Clinic, Rochester, Minnesota;

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Christopher G. Schwarz

1Department of Radiology, Mayo Clinic, Rochester, Minnesota;

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Hugo Botha

5Department of Neurology, Mayo Clinic, Rochester, Minnesota; and

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Jonathan Graff-Radford

5Department of Neurology, Mayo Clinic, Rochester, Minnesota; and

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David T. Jones

5Department of Neurology, Mayo Clinic, Rochester, Minnesota; and

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Prashanthi Vemuri

1Department of Radiology, Mayo Clinic, Rochester, Minnesota;

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Kejal Kantarci

1Department of Radiology, Mayo Clinic, Rochester, Minnesota;

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David S. Knopman

5Department of Neurology, Mayo Clinic, Rochester, Minnesota; and

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Ronald C. Petersen

5Department of Neurology, Mayo Clinic, Rochester, Minnesota; and

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Clifford R. Jack Jr.

1Department of Radiology, Mayo Clinic, Rochester, Minnesota;

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Jeyeon Lee

1Department of Radiology, Mayo Clinic, Rochester, Minnesota;

6Department of Biomedical Engineering, College of Medicine, Hanyang University, Seoul, South Korea

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Val J. Lowe

1Department of Radiology, Mayo Clinic, Rochester, Minnesota;

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Vol. 65, Issue 7

July 1, 2024

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Patterns of Early Neocortical Amyloid-β Accumulation: A PET Population-Based Study

Journal of Nuclear Medicine Jul 2024, 65 (7) 1122-1128; DOI: 10.2967/jnumed.123.267150

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Patterns of Early Neocortical Amyloid-β Accumulation: A PET Population-Based Study

Journal of Nuclear Medicine Jul 2024, 65 (7) 1122-1128; DOI: 10.2967/jnumed.123.267150

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Keywords

amyloid-β
Pittsburgh compound B
PiB
PET
early stage

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