Kinetic Analysis and Metabolism of Poly(Adenosine Diphosphate–Ribose) Polymerase-1–Targeted 18F-Fluorthanatrace PET in Breast Cancer

Anthony J. Young; Austin R. Pantel; Mahsa Kiani; Robert K. Doot; Sina Bagheri; Daniel A. Pryma; Michael D. Farwell; Shihong Li; Hsiaoju Lee; Erin K. Schubert; Anthony Secreto; Samantha P. Zuckerman; Anupma Nayak; Hoon Choi; Sean Carlin; Angela DeMichele; David A. Mankoff; Rong Zhou; Robert H. Mach; Elizabeth S. McDonald

doi:10.2967/jnumed.124.268254

Research ArticleClinical Investigation

Kinetic Analysis and Metabolism of Poly(Adenosine Diphosphate–Ribose) Polymerase-1–Targeted ¹⁸F-Fluorthanatrace PET in Breast Cancer

Anthony J. Young, Austin R. Pantel, Mahsa Kiani, Robert K. Doot, Sina Bagheri, Daniel A. Pryma, Michael D. Farwell, Shihong Li, Hsiaoju Lee, Erin K. Schubert, Anthony Secreto, Samantha P. Zuckerman, Anupma Nayak, Hoon Choi, Sean Carlin, Angela DeMichele, David A. Mankoff, Rong Zhou, Robert H. Mach and Elizabeth S. McDonald

Journal of Nuclear Medicine December 2024, 65 (12) 1862-1868; DOI: https://doi.org/10.2967/jnumed.124.268254

Anthony J. Young

1Department of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania;

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Austin R. Pantel

1Department of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania;

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Mahsa Kiani

1Department of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania;

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Robert K. Doot

1Department of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania;

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Sina Bagheri

1Department of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania;

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Daniel A. Pryma

1Department of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania;

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Michael D. Farwell

1Department of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania;

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Shihong Li

1Department of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania;

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Hsiaoju Lee

1Department of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania;

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Erin K. Schubert

1Department of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania;

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Anthony Secreto

2Department of Hematology and Oncology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania;

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Samantha P. Zuckerman

1Department of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania;

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Anupma Nayak

3Department of Pathology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania;

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Hoon Choi

1Department of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania;

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Sean Carlin

4Invicro LLC, Needham, Massachusetts; and

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Angela DeMichele

5Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania

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David A. Mankoff

1Department of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania;

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Rong Zhou

1Department of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania;

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Robert H. Mach

1Department of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania;

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Elizabeth S. McDonald

1Department of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania;

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Vol. 65, Issue 12

December 1, 2024

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Kinetic Analysis and Metabolism of Poly(Adenosine Diphosphate–Ribose) Polymerase-1–Targeted ¹⁸F-Fluorthanatrace PET in Breast Cancer

Journal of Nuclear Medicine Dec 2024, 65 (12) 1862-1868; DOI: 10.2967/jnumed.124.268254

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Kinetic Analysis and Metabolism of Poly(Adenosine Diphosphate–Ribose) Polymerase-1–Targeted ¹⁸F-Fluorthanatrace PET in Breast Cancer

Journal of Nuclear Medicine Dec 2024, 65 (12) 1862-1868; DOI: 10.2967/jnumed.124.268254

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Keywords

18F-fluorthanatrace
breast cancer
radiotracer tissue pharmacokinetics
PARP-1

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