Table of Contents

August 1, 2023; Volume 64,Issue 8

This Month in JNM

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This Month in JNM
Journal of Nuclear Medicine August 1, 2023, 64 (8) 6A;

Discussions with Leaders

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A Life Study in Academic Leadership
Carolyn C. Meltzer and Hossein Jadvar

Journal of Nuclear Medicine August 1, 2023, 64 (8) 1167-1170; DOI: https://doi.org/10.2967/jnumed.123.266097

State of the Art

Open Access
The Use of Tau PET to Stage Alzheimer Disease According to the Braak Staging Framework
Arthur C. Macedo, Cécile Tissot, Joseph Therriault, Stijn Servaes, Yi-Ting Wang, Jaime Fernandez-Arias, Nesrine Rahmouni, Firoza Z. Lussier, Marie Vermeiren, Gleb Bezgin, Paolo Vitali, Kok Pin Ng, Eduardo R. Zimmer, Marie-Christine Guiot, Tharick A. Pascoal, Serge Gauthier and Pedro Rosa-Neto

Journal of Nuclear Medicine August 1, 2023, 64 (8) 1171-1178; DOI: https://doi.org/10.2967/jnumed.122.265200

Focus on Molecular Imaging

Open Access
Molecular Imaging, Radiochemistry, and Environmental Pollutants
Samantha Delaney, Joni Sebastiano, Brian M. Zeglis and Outi M. Keinänen

Journal of Nuclear Medicine August 1, 2023, 64 (8) 1179-1184; DOI: https://doi.org/10.2967/jnumed.122.265209

Oncology

Clinical
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  Evaluation of [⁶⁸Ga]-DOTATOC PET/MRI in Patients with Meningioma of the Subcranial and Intraorbital Space
  Aleksandar Milosevic, Hanna Styczen, Johannes Grueneisen, Yan Li, Manuel Weber, Wolfgang P. Fendler, Julian Kirchner, Philipp Damman, Karsten Wrede, Lazaros Lazaridis, Martin Glas, Maja Guberina, Anja Eckstein, Tobias Blau, Ken Herrmann, Lale Umutlu, Michael Forsting, Cornelius Deuschl and Benedikt Schaarschmidt
  
  Journal of Nuclear Medicine August 1, 2023, 64 (8) 1185-1190; DOI: https://doi.org/10.2967/jnumed.123.265424
- BRIEF COMMUNICATION
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    SUV_max Above 20 in ¹⁸F-FDG PET/CT at Initial Diagnostic Workup Associates with Favorable Survival in Patients with Cancer of Unknown Primary
    Gregor Zaun, Manuel Weber, Martin Metzenmacher, Marcel Wiesweg, Thomas Hilser, Yasmin Zaun, Sven Liffers, Michael Pogorzelski, Isabel Virchow, Wilfried Eberhardt, Sarah Theurer, Tanja Abu Sabbah, Timm M. Reissig, Martin Stuschke, Cornelius Kürten, Timon Hussain, Stephan Lang, Stefan Kasper, Wolfgang P. Fendler, Ken Herrmann and Martin Schuler
    
    Journal of Nuclear Medicine August 1, 2023, 64 (8) 1191-1194; DOI: https://doi.org/10.2967/jnumed.122.265161
Basic
- FEATURED BASIC SCIENCE ARTICLE
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    Metformin-Induced Receptor Turnover Alters Antibody Accumulation in HER-Expressing Tumors
    Sandeep Surendra Panikar, Nai Keltee, Na-Keysha Berry, Shayla Shmuel, Zachary T. Fisher, Emma Brown, Abbey Zidel, Alex Mabry and Patrícia M.R. Pereira
    
    Journal of Nuclear Medicine August 1, 2023, 64 (8) 1195-1202; DOI: https://doi.org/10.2967/jnumed.122.265248
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  Pretargeting with Cucurbituril–Adamantane Host–Guest Pair in Xenograft Models
  Vilma I.J. Jallinoja, Courtney H. Abbriano, Kavita Bhatt, Amritjyot Kaur, David J. Schlyer, Paul J. Yazaki, Brandon D. Carney and Jacob L. Houghton
  
  Journal of Nuclear Medicine August 1, 2023, 64 (8) 1203-1209; DOI: https://doi.org/10.2967/jnumed.122.265008

Theranostics

Clinical
- Open Access
  Clinical Evaluation of ⁶⁸Ga-FAPI-RGD for Imaging of Fibroblast Activation Protein and Integrin α_vβ₃ in Various Cancer Types
  Liang Zhao, Xuejun Wen, Weizhi Xu, Yizhen Pang, Long Sun, Xiaoming Wu, Pengfei Xu, Jingjing Zhang, Zhide Guo, Qin Lin, Xiaoyuan Chen and Haojun Chen
  
  Journal of Nuclear Medicine August 1, 2023, 64 (8) 1210-1217; DOI: https://doi.org/10.2967/jnumed.122.265383
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  Evaluation of the Diagnostic Accuracy of FAPI PET/CT in Oncologic Studies: Systematic Review and Metaanalysis
  Grayson Wass, Kari Clifford and Rathan M. Subramaniam
  
  Journal of Nuclear Medicine August 1, 2023, 64 (8) 1218-1224; DOI: https://doi.org/10.2967/jnumed.123.265471
- Open Access
  Initial Evaluation of [¹⁸F]FAPI-74 PET for Various Histopathologically Confirmed Cancers and Benign Lesions
  Tadashi Watabe, Sadahiro Naka, Mitsuaki Tatsumi, Takashi Kamiya, Toru Kimura, Yasushi Shintani, Kaori Abe, Tomohiro Miyake, Kenzo Shimazu, Shogo Kobayashi, Yukinori Kurokawa, Hidetoshi Eguchi, Yuichiro Doki, Hidenori Inohara, Hiroki Kato, Yuriko Mori, Jens Cardinale and Frederik L. Giesel
  
  Journal of Nuclear Medicine August 1, 2023, 64 (8) 1225-1231; DOI: https://doi.org/10.2967/jnumed.123.265486
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  Tumor Characterization by [⁶⁸Ga]FAPI-46 PET/CT Can Improve Treatment Selection for Pancreatic Cancer Patients: An Interim Analysis of a Prospective Clinical Trial
  Pawel Rasinski, Siri af Burén, Maria Holstensson, Ted Nilsson, Louiza Loizou, Thuy A. Tran, Ernesto Sparrelid, J. Matthias Löhr and Rimma Axelsson
  
  Journal of Nuclear Medicine August 1, 2023, 64 (8) 1232-1237; DOI: https://doi.org/10.2967/jnumed.123.265481
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  The Diagnostic Value of PSMA PET/CT in Men with Newly Diagnosed Unfavorable Intermediate-Risk Prostate Cancer
  Marinus J. Hagens, Wietske I. Luining, Auke Jager, Maarten L. Donswijk, Zing Cheung, Maurits Wondergem, Daniela E. Oprea-Lager, André N. Vis, Pim J. van Leeuwen and Henk G. van der Poel
  
  Journal of Nuclear Medicine August 1, 2023, 64 (8) 1238-1243; DOI: https://doi.org/10.2967/jnumed.122.265205
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  Safety and Efficacy of [¹⁷⁷Lu]-PSMA-I&T Radioligand Therapy in Octogenarians with Metastatic Castration-Resistant Prostate Cancer: Report on 80 Patients over the Age of 80 Years
  Robert Tauber, Karina Knorr, Margitta Retz, Isabel Rauscher, Sonia Grigorascu, Kimberley Hansen, Calogero D’Alessandria, Hans-Jürgen Wester, Jürgen Gschwend, Wolfgang Weber, Matthias Eiber and Thomas Langbein
  
  Journal of Nuclear Medicine August 1, 2023, 64 (8) 1244-1251; DOI: https://doi.org/10.2967/jnumed.122.265259
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  The Impact of PSMA PET–Based Eligibility Criteria Used in the Prospective Phase II TheraP Trial in Metastatic Castration-Resistant Prostate Cancer Patients Undergoing Prostate-Specific Membrane Antigen–Targeted Radioligand Therapy
  Amir Karimzadeh, Matthias Heck, Robert Tauber, Esteban Solaris, Stephan Nekolla, Karina Knorr, Bernhard Haller, Calogero D’Alessandria, Wolfgang A. Weber, Matthias Eiber and Isabel Rauscher
  
  Journal of Nuclear Medicine August 1, 2023, 64 (8) 1252-1258; DOI: https://doi.org/10.2967/jnumed.122.265346
- Open Access
  A VISION Substudy of Reader Agreement on ⁶⁸Ga-PSMA-11 PET/CT Scan Interpretation to Determine Patient Eligibility for ¹⁷⁷Lu-PSMA-617 Radioligand Therapy
  Phillip H. Kuo, Don C. Yoo, Ryan Avery, Marc Seltzer, Jeremie Calais, James Nagarajah, Wolfgang A. Weber, Wolfgang P. Fendler, Michael S. Hofman, Bernd J. Krause, Marcia Brackman, Euloge Kpamegan, Samson Ghebremariam, Taylor Benson, Ana M. Catafau and Ayse T. Kendi
  
  Journal of Nuclear Medicine August 1, 2023, 64 (8) 1259-1265; DOI: https://doi.org/10.2967/jnumed.122.265077
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  [¹⁷⁷Lu]Lu-PSMA-Radioligand Therapy Efficacy Outcomes in Taxane-Naïve Versus Taxane-Treated Patients with Metastatic Castration-Resistant Prostate Cancer: A Systematic Review and Metaanalysis
  Swayamjeet Satapathy, Ranjit K. Sahoo and Chandrasekhar Bal
  
  Journal of Nuclear Medicine August 1, 2023, 64 (8) 1266-1271; DOI: https://doi.org/10.2967/jnumed.123.265414
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  Elevated Body Mass Index Is Associated with Improved Overall Survival in Castration-Resistant Prostate Cancer Patients Undergoing Prostate-Specific Membrane Antigen–Directed Radioligand Therapy
  Philipp E. Hartrampf, Patrick W. Mihatsch, Anna Katharina Seitz, Lilja B. Solnes, Steven P. Rowe, Martin G. Pomper, Hubert Kübler, Thorsten A. Bley, Andreas K. Buck and Rudolf A. Werner
  
  Journal of Nuclear Medicine August 1, 2023, 64 (8) 1272-1278; DOI: https://doi.org/10.2967/jnumed.122.265379

Cardiovascular

Clinical
- FEATURED ARTICLE OF THE MONTH
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    Molecular Imaging of Myocardial Fibroblast Activation in Patients with Advanced Aortic Stenosis Before Transcatheter Aortic Valve Replacement: A Pilot Study
    Johanna Diekmann, Jonas Neuser, Manuel Röhrich, Thorsten Derlin, Carolin Zwadlo, Tobias Koenig, Desiree Weiberg, Felix Jäckle, Tibor Kempf, Tobias L. Ross, Jochen Tillmanns, James T. Thackeray, Julian Widder, Uwe Haberkorn, Johann Bauersachs and Frank M. Bengel
    
    Journal of Nuclear Medicine August 1, 2023, 64 (8) 1279-1286; DOI: https://doi.org/10.2967/jnumed.122.265147

Infectious Disease

Clinical
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  Importance of Blood Glucose Management Before ¹⁸F-FDG PET/CT in 322 Patients with Bacteremia of Unknown Origin
  Jordy P. Pijl, Andor W.J.M. Glaudemans, Olivier Gheysens, Riemer H.J.A. Slart and Thomas C. Kwee
  
  Journal of Nuclear Medicine August 1, 2023, 64 (8) 1287-1294; DOI: https://doi.org/10.2967/jnumed.122.264839

Radiobiology/Dosimetry

Clinical
- SPECIAL CONTRIBUTION
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    MIRD Pamphlet No. 28, Part 2: Comparative Evaluation of MIRDcalc Dosimetry Software Across a Compendium of Diagnostic Radiopharmaceuticals
    Lukas M. Carter, Juan C. Ocampo Ramos, Edmond A. Olguin, Justin L. Brown, Daniel Lafontaine, Derek W. Jokisch, Wesley E. Bolch and Adam L. Kesner
    
    Journal of Nuclear Medicine August 1, 2023, 64 (8) 1295-1303; DOI: https://doi.org/10.2967/jnumed.122.264230

AI/Advanced Image Analysis

Clinical
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  Facial Anonymization and Privacy Concerns in Total-Body PET/CT
  Aaron R. Selfridge, Benjamin A. Spencer, Yasser G. Abdelhafez, Keisuke Nakagawa, John D. Tupin and Ramsey D. Badawi
  
  Journal of Nuclear Medicine August 1, 2023, 64 (8) 1304-1309; DOI: https://doi.org/10.2967/jnumed.122.265280

Molecular Imaging

Clinical
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  - Open Access
    Endogenous Opioid Release After Orgasm in Man: A Combined PET/Functional MRI Study
    Patrick Jern, Jinglu Chen, Jouni Tuisku, Tiina Saanijoki, Jussi Hirvonen, Lasse Lukkarinen, Sandra Manninen, Semi Helin, Vesa Putkinen and Lauri Nummenmaa
    
    Journal of Nuclear Medicine August 1, 2023, 64 (8) 1310-1313; DOI: https://doi.org/10.2967/jnumed.123.265512
Basic
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  Comparative Evaluation of [¹⁸F]5-Fluoroaminosuberic Acid and (4S)-4-3-[¹⁸F]fluoropropyl)-l-Glutamate as System $\text{[math]}$ –Targeting Radiopharmaceuticals
  Milena Colovic, Hua Yang, Lily Southcott, Helen Merkens, Nadine Colpo, Francois Bénard and Paul Schaffer
  
  Journal of Nuclear Medicine August 1, 2023, 64 (8) 1314-1321; DOI: https://doi.org/10.2967/jnumed.122.265254

Illustrated Post

Clinical
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  ¹⁶¹Tb-PSMA Radioligand Therapy: First-in-Humans SPECT/CT Imaging
  Akram Al-Ibraheem, Rahma M. Doudeen, Diyaa Juaidi, Alaa Abufara and Stephan Maus
  
  Journal of Nuclear Medicine August 1, 2023, 64 (8) 1322-1323; DOI: https://doi.org/10.2967/jnumed.122.265291

Letters to the Editor

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Radiopharmaceutical Extravasations Can Have Consequences
Dale L. Bailey

Journal of Nuclear Medicine August 1, 2023, 64 (8) 1324; DOI: https://doi.org/10.2967/jnumed.123.265717
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Reply: Radiopharmaceutical Extravasations CanHave Consequences
Ashwin Singh Parihar, Lisa Raymond-Schmidt, John P. Crandall, Farrokh Dehdashti and Richard L. Wahl

Journal of Nuclear Medicine August 1, 2023, 64 (8) 1324-1325; DOI: https://doi.org/10.2967/jnumed.123.265920
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PSMA Is Not Specific to Prostate Cancer
Loic Ah-Thiane, Ludovic Ferrer and Caroline Rousseau

Journal of Nuclear Medicine August 1, 2023, 64 (8) 1326; DOI: https://doi.org/10.2967/jnumed.123.265720
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Reply: PSMA Is Not Specific to Prostate Cancer
Susan Notohamiprodjo, Matthias Eiber, Christian Lohrmann and Wolfgang A. Weber

Journal of Nuclear Medicine August 1, 2023, 64 (8) 1326-1327; DOI: https://doi.org/10.2967/jnumed.123.265921