Cohort 1 ([18F]GTP1 and [18F]PI-2620) SUVR Quantification in Target Regions
| ROI | [18F]GTP1 SUVR | [18F]PI-2620 SUVR | SUVR difference ([18F]GTP1 − [18F]PI-2620) | r2 (95% CI) | Slope (95% CI) | Intercept (95% CI) |
|---|---|---|---|---|---|---|
| Braak I | 1.61 ± 0.24 | 1.71 ± 0.29 | −0.10 ± 0.16 | 0.71* (0.50–0.84) | 1.28 (1.03–1.73) | −0.35 (−1.10–0.03) |
| Braak II | 1.32 ± 0.15 | 1.21 ± 0.17 | 0.11 ± 0.16* | 0.28* (0.05–0.49) | 1.14 (0.51–2.33) | −0.29 (−1.88–0.52) |
| Braak III | 1.42 ± 0.23 | 1.47 ± 0.34 | −0.05 ± 0.15 | 0.86* (0.73–0.93) | 1.51 (1.28–1.93) | −0.67 (−1.25 to −0.36) |
| Braak IV | 1.61 ± 0.40 | 1.72 ± 0.51 | −0.11 ± 0.18* | 0.91* (0.80–0.96) | 1.29 (1.15–1.59) | −0.36 (−0.80 to −0.16) |
| Braak V | 1.25 ± 0.21 | 1.29 ± 0.27 | −0.04 ± 0.12 | 0.82* (0.64–0.91) | 1.30 (1.06–1.68) | −0.34 (−0.77 to −0.06) |
| Braak VI | 1.07 ± 0.13 | 1.10 ± 0.18 | −0.03 ± 0.09 | 0.78* (0.54–0.91) | 1.46 (1.12–1.80) | −0.46 (−0.83 to −0.09) |
| Meta temporal | 1.58 ± 0.35 | 1.74 ± 0.44 | −0.16 ± 0.16* | 0.90* (0.79–0.94) | 1.29 (1.12–1.54) | −0.31 (−0.66 to −0.07) |
| Whole cortical gray | 1.29 ± 0.23 | 1.39 ± 0.27 | −0.10 ± 0.11* | 0.86* (0.72–0.92) | 1.23 (1.04–1.52) | −0.19 (−0.53–0.07) |
↵* Indicates P (Bonferroni) < 0.05.
Slope of 2 indicates that for one-unit change in SUVR of [18F]GTP1, there is corresponding change in SUVR of 2 of [18F]PI-2620, on average.
Continuous data are median and range.