RT Journal Article
SR Electronic
T1 Nuclear Imaging of Bispecific Antibodies on the Rise
JF Journal of Nuclear Medicine
JO J Nucl Med
FD Society of Nuclear Medicine
SP 1512
OP 1517
DO 10.2967/jnumed.123.267215
VO 65
IS 10
A1 Roohani, Borna
A1 Mendez, Aldred Shane
A1 Dangarwala, Mann
A1 Katz, Samantha
A1 Marquez-Nostra, Bernadette
YR 2024
UL http://jnm.snmjournals.org/content/65/10/1512.abstract
AB Bispecific antibodies (bsAbs) are engineered to target 2 different epitopes simultaneously. About 75% of the 16 clinically approved bsAbs have entered the clinic internationally since 2022. Hence, research on biomedical imaging of various radiolabeled bsAb scaffolds may serve to improve patient selection for bsAb therapy. Here, we provide a comprehensive overview of recent advances in radiolabeled bsAbs for imaging via PET or SPECT. We compare direct targeting and pretargeting approaches in preclinical and clinical studies in oncologic research. Furthermore, we show preclinical applications of imaging bsAbs in neurodegenerative diseases. Finally, we offer perspectives on the future directions of imaging bsAbs based on their challenges and opportunities.