PT  - JOURNAL ARTICLE
AU  - Kesner, Adam L.
AU  - Carter, Lukas M.
AU  - Ramos, Juan C. Ocampo
AU  - Lafontaine, Daniel
AU  - Olguin, Edmond A.
AU  - Brown, Justin L.
AU  - President, Bonnie
AU  - Jokisch, Derek W.
AU  - Fisher, Darrell R.
AU  - Bolch, Wesley E.
TI  - MIRD Pamphlet No. 28, Part 1: MIRDcalc—A Software Tool for Medical Internal Radiation Dosimetry
AID  - 10.2967/jnumed.122.264225
DP  - 2023 Jul 01
TA  - Journal of Nuclear Medicine
PG  - 1117--1124
VI  - 64
IP  - 7
4099  - http://jnm.snmjournals.org/content/64/7/1117.short
4100  - http://jnm.snmjournals.org/content/64/7/1117.full
SO  - J Nucl Med2023 Jul 01; 64
AB  - Medical internal radiation dosimetry constitutes a fundamental aspect of diagnosis, treatment, optimization, and safety in nuclear medicine. The MIRD committee of the Society of Nuclear Medicine and Medical Imaging developed a new computational tool to support organ-level and suborgan tissue dosimetry (MIRDcalc, version 1). Based on a standard Excel spreadsheet platform, MIRDcalc provides enhanced capabilities to facilitate radiopharmaceutical internal dosimetry. This new computational tool implements the well-established MIRD schema for internal dosimetry. The spreadsheet incorporates a significantly enhanced database comprising details for 333 radionuclides, 12 phantom reference models (International Commission on Radiological Protection), 81 source regions, and 48 target regions, along with the ability to interpolate between models for patient-specific dosimetry. The software also includes sphere models of various composition for tumor dosimetry. MIRDcalc offers several noteworthy features for organ-level dosimetry, including modeling of blood source regions and dynamic source regions defined by user input, integration of tumor tissues, error propagation, quality control checks, batch processing, and report-preparation capabilities. MIRDcalc implements an immediate, easy-to-use single-screen interface. The MIRDcalc software is available for free download (www.mirdsoft.org) and has been approved by the Society of Nuclear Medicine and Molecular Imaging.